Medicinal Chemistry

Iole Cerminara

Publications

• Research Article
  Heterocycles for Alzheimer Disease: 4- and 5-Substituted Benzothiophenes as Starting Scaffold in the Construction of Potential New Inhibitors of BACE 1
  Author(s): Maria Funicello, Iole Cerminara and Lucia ChiummientoMaria Funicello, Iole Cerminara and Lucia Chiummiento
  
  4- and 5-substituted benzothiophenes were synthesized as starting scaffold in the construction of benzothieno[b] pyridines. Such structures were designed as potential new inhibitors of BACE 1. Preliminary promising biological data were reported. These molecules represent a starting point for improved chemicals in Alzheimer’s disease treatment. Obtained preliminary results encourage research advance and further developments. .. Read More»
  DOI: 10.4172/2161-0444.1000373

  Abstract PDF