Medicinal Chemistry

Irasema Anaya-Sosa

Publications

• Research Article
  Inhibitory Activities of Guaianolides from the Seeds of Byrsonima Crassifolia against Protein Glycation In Vitro
  Author(s): Rosa Martha Perez-Gutierrez, Alethia Muñiz-Ramirez, Irasema Anaya-Sosa, Teresa Cruz-Victoria and Jose Maria Mota-FloresRosa Martha Perez-Gutierrez, Alethia Muñiz-Ramirez, Irasema Anaya-Sosa, Teresa Cruz-Victoria and Jose Maria Mota-Flores
  
  In-depth chromatographicinvestigation on the hexane extract of Byrsonima crassifolia led to the identification of eight new guaianolides. Structural elucidation was established on the basis of spectral data as; byrsonina C (1) to byrsonina J (8). In vitro inhibitory activity of the 1-8 on advanced glycationend products (AGEs), analysis of protein gels (SDS-PAGE) profile and by matrix assisted laser desorption ionization (MALDI) coupled to time of flight (TOF) analyzers mass spectra (MALDI lineal TOF MS) were evaluated. Guaianolides exhibited glycation inhibitory activity similar to that of aminoguanidine. The major mechanism implied in the inhibition of protein glycation by compounds 1-8 was attributed to their ability to react with carbonyls. SDS-PAGE profiles displayed inhibition of AGE generation, through inhibition of the crosslin.. Read More»
  DOI: 10.4172/2161-0444.1000267

  Abstract PDF