Journal of Biometrics & Biostatistics

Isaac Dialsingh

Publications

• Research Article
  Comparison of Methods for Estimating the Proportion of Null Hypotheses �?�?�?�0 in High Dimensional Data When the Test Statistics is Continuous
  Author(s): Isaac Dialsingh and Sherwin P CedenoIsaac Dialsingh and Sherwin P Cedeno
  
  Advances in Genomics have re-energized interest in multiple hypothesis testing procedures but have simultaneously created new methodological and computational challenges. In Genomics for instance, it is now commonplace for experiments to measure expression levels in thousands of genes creating large multiplicity problems when thousands of hypotheses are to be tested simultaneously. Within this context we seek to identify differentially expressed genes, that is, genes whose expression levels are associated with a particular response or covariate of interest. The False Discovery Rate (FDR) is the preferred measure since the Family Wise Error Rates (FWERs) are usually overly restrictive. In the FDR methods, estimation of the proportion of null hypotheses (π0) is an important parameter that needs to be estimated.      In this paper, we compare the effectiveness of 1.. Read More»
  DOI: 10.4172/2155-6180.1000343

  Abstract PDF