Journal of Dermatology and Dermatologic Diseases

Ish Pandhi

Publications

• Review Article
  Melanocytic Tumors of the Skin: A Dermatopathological Review
  Author(s): Ish Pandhi, Shashi Bhushan Pandhi, Sunil Alipuria Pandhi and Sonam Ish PandhiIsh Pandhi, Shashi Bhushan Pandhi, Sunil Alipuria Pandhi and Sonam Ish Pandhi
  
  Diagnosis of melanocytic tumors poses two big problems for a histopathologist, firstly to diagnose it as melanocytic tumor and the other important problem is the determination of whether the lesion of obvious melanocytic nature is benign or malignant. Here we wish to provide few key histopathological features of some important tumors that will guide a histopathologist in overcoming these problems Melanocytes are generally positive for melanin stains (such as the Fontana- Masson silver stain), tyrosinase, DOPA reaction, S-100 protein, NSE, Mart-1/MelanA (A103), microphthalmia transcription factor, Sox10 (a neural crest transcription factor) PAX3 (a transcription factor with an important role in the development of melanocytes during embryogenesis), and vimentin; the intensity of these reactions shows marked variability, possibly depending on the functional status of the cell. Stains for.. Read More»
  DOI: 10.4172/2376-0427.1000118

  Abstract PDF