Journal of AIDS & Clinical Research

Jacopo Vecchiet

Publications

• Research Article
  A Four-Drug Induction Therapy Including Raltegravir for the Treatment of NaÃ?Æ?Ã?¯ve HIV-Infected Patients
  Author(s): Katia Falasca, Claudio Ucciferri, Marta Di Nicola, Francesca Vignale, Delia Racciatti and Jacopo VecchietKatia Falasca, Claudio Ucciferri, Marta Di Nicola, Francesca Vignale, Delia Racciatti and Jacopo Vecchiet
  
  Background: Despite the recent advances in antiretroviral therapy, human immunodeficiency virus type 1 (HIV-1) remains a global health threat. The aim of this study was evaluated the efficacy of a four-drug induction antiretroviral therapy (ART), including raltegravir (RAL), on the rapidity of suppression of plasma HIV-RNA below detectable concentrations and its impact on immunological recovery. Methods: In this single centre, randomized prospective trial, 32 naïve HIV+ patients at the same clinical stage were enrolled and randomized for baseline viral load: sixteen subjects started ART with four antiretroviral drugs including RAL, while the remaining patients started the same therapy without RAL. Viro-immunological and metabolic parameters, indexes of hepatic and renal functionality were measured at baseline (T0) and after three (T3), six (T6) and twelve months (T12) from thera.. Read More»
  DOI: 10.4172/2155-6113.1000705

  Abstract PDF