Medicinal Chemistry

Jameleddine Saloua

Publications

• Research Article
  Protective Effect of ATRA on Bleomycin Induced Lung Fibrosis in Rat
  Author(s): Serairi Beji Raja, Msilini Najoua, Abidi Anouar, Saidi Oussama, Jameleddine Saloua and Ksouri RiadhSerairi Beji Raja, Msilini Najoua, Abidi Anouar, Saidi Oussama, Jameleddine Saloua and Ksouri Riadh
  
  All-trans-retinoic acid (ATRA), an active metabolite of vitamin A, is known to affect cell differentiation, proliferation, and development. Pulmonary fibrosis is one of the most common chronic interstitial lung diseases with high mortality rate after diagnosis and limited successful treatment. The aim of this study is to assess the effects of ATRA against bleomycin-induced pulmonary fibrosis in rats. Animals were intratracheally instillated with bleomycin and/or intraperitoneally administered with ATRA. On day 28, rats were sacrificed and histological changes in the lungs were evaluated. Moreover, malondialdehyde (MDA) content, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities in serum and lung, were achieved. Results displayed that rat body weight decreased while fibrosis score and inflammatory in.. Read More»
  DOI: 10.4172/2161-0444.1000202

  Abstract PDF