Molecular Biomarkers & Diagnosis

James Eric McDuffie

Publications

• Research Article
  Feasibility of Protein Biomarkers in the Prediction of Subclinical Doxorubicin Nephrotoxicity in Male Sprague-Dawley Rat
  Author(s): James Eric McDuffie, Manisha Sonee, Jing Ma, Frederic Almy, Xuejun Liu, David La and Sandra SnookJames Eric McDuffie, Manisha Sonee, Jing Ma, Frederic Almy, Xuejun Liu, David La and Sandra Snook
  
  The feasibility of proteinbiomarkers in the prediction of subclinical doxorubicin nephrotoxicity was evaluated in male Sprague-Dawley rats during a 2-week study with once‑weekly dosing. Doxorubicin (5, 7.5, and 10 mg/kg/ dose) or 0.9% Saline was intravenously administered on days 1 and 8. Urine and serum were collected at various time points. Surviving animals were euthanized on day 14, and tissues were collected for microscopic examination. Severe clinical signs were observed in the 7.5 and 10 mg/kg/dose groups. Biomarker data are not reported for these groups because the objective of this study was to evaluate biomarkers at doses not associated with clinical signs. In the 5 mg/kg group, increased serum concentrations of urea nitrogen were observed on day 14 with concurrent renal histopathology findings which were primarily characterized as slight ren.. Read More»
  DOI: 10.4172/2155-9929.1000165

  Abstract PDF