Journal of Nephrology & Therapeutics

James Hardin

Publications

• Research Article
  Relationship of Race and Proteinuria to Renal Function Decline in Patients with CKD
  Author(s): Steven Rosansky, Martin Durkin, James Hardin, Kirby Jackson, Csaba Kovesdy, Jessica Sontrop, Justin Reynolds, Kathlyn Haddock, Frankie Richards and William ClarkSteven Rosansky, Martin Durkin, James Hardin, Kirby Jackson, Csaba Kovesdy, Jessica Sontrop, Justin Reynolds, Kathlyn Haddock, Frankie Richards and William Clark
  
  Background: To date, the reasons for the higher rates of treated end-stage renal failure in blacks versus whites are poorly understood. Proteinuria is the most important determinant of renal function loss (RFL). Blacks have a higher incidence of proteinuric CKD than whites. The current study evaluates the hypothesis that after adjustment for proteinuria, blacks have faster RFL, more prominent at lower levels of estimated glomerular filtration rates (eGFR). Methods: In a non-referral outpatient CKD population of 1,935 blacks and 6,286 whites, the relationship of zero, <2 plus and ≥ 2 plus dipstick proteinuria to MDRD e GFR change per year (RFL) was analyzed. Next the relationship between race and RFL was examined in patients with higher versus lower eGFR (defined by never or ever having an eGFR <30 ml/min/1.73 m2, respectively during the study using a mixed effects model which.. Read More»
  DOI: 10.4172/2161-0959.1000168

  Abstract PDF