Pulmonary & Respiratory Medicine

James P Maloney

Publications

• Research Article
  Platelet Vascular Endothelial Growth Factor is a Potential Mediator of Transfusion-Related Acute Lung Injury
  Author(s): James P Maloney, Daniel R Ambruso, Norbert F Voelkel and Christopher C SillimanJames P Maloney, Daniel R Ambruso, Norbert F Voelkel and Christopher C Silliman
  
  Objective: The occurrence of non-hemolytic transfusion reactions is highest with platelet and plasma administration. Some of these reactions are characterized by endothelial leak, especially transfusion related acute lung injury (TRALI). Elevated concentrations of inflammatory mediators secreted by contaminating leukocytes during blood product storage may contribute to such reactions, but platelet-secreted mediators may also contribute. We hypothesized that platelet storage leads to accumulation of the endothelial permeability mediator vascular endothelial growth factor (VEGF), and that intravascular administration of exogenous VEGF leads to extensive binding to its lung receptors. Methods: Single donor, leukocyte-reduced apheresis platelet units were sampled over 5 days of storage. VEGF protein content of the centrifuged supernatant was determined by ELISA, and the potentia.. Read More»
  DOI: 10.4172/2161-105X.1000212

  Abstract PDF