Journal of Nephrology & Therapeutics

Jamil Hachicha

Publications

• Research Article
  A Clinical Experience on Sulodexide in the Treatment of Patients with Diabetic Nephropathy
  Author(s): Sabeur Dakhli, Adel Khedher, Zidi Borni, Abdellatif Achour and Jamil HachichaSabeur Dakhli, Adel Khedher, Zidi Borni, Abdellatif Achour and Jamil Hachicha
  
  Background: Diabetic nephropathy, characterized by albuminuria, is a severe complication of diabetes mellitus, leading cause of end-stage renal disease. The aim of the present study was to evaluate the efficacy and safety of sulodexide, alone or in combination with captopril, versus captopril alone in consecutive adult patients with diabetic nephropathy. Methods: Patients aged ≥ 18 years, with type 1 or type 2 diabetes mellitus and albumin excretion rate (AER) ≥ 30 mg/24 h, without severe renal insufficiency, cardiac or hepatic insufficiency, or haematuria, were enrolled. Patients were treated with captopril 25 mg twice daily, sulodexide 25 mg twice daily, or a combination of captopril 25 mg twice daily + sulodexide 25 mg twice daily for 6 months. The primary endpoint was the evaluation of AER. Secondary endpoints included evaluation of arterial blood pressure, fasting glucose,.. Read More»
  DOI: 10.4172/2161-0959.1000284

  Abstract PDF