Journal of Tissue Science and Engineering

Jan Czernuszka

Publications

• Research Article
  Collagen-Based Scaffolds for Potential Application of Heart Valve Tissue Engineering
  Author(s): Qi Chen, Arne Bruyneel, Kieran Clarke, Carolyn Carr and Jan CzernuszkaQi Chen, Arne Bruyneel, Kieran Clarke, Carolyn Carr and Jan Czernuszka
  
  Collagen, glycosaminoglycans and elastin are the major components of heart valves. This work examines the roles of the composition of the collagen-based scaffolds on the microstructures, mechanical properties, and bioactivities. Scaffolds (with up to 80% elastin or 50% chondroitin-4-sulfate) were prepared by freeze drying suspensions of various compositions. The as-prepared scaffolds had mean pore sizes ranging from 115.6 μm to 187.6 μm. Mechanical characterizations showed that the scaffolds behaved as elastomers, and their characteristic mechanical properties were also dependent on the composition. The tensile, compressive, and bending modulus ranged from 39.8 ± 8.8 kPa, 10.2 ± 1.6 kPa, and 25.4 ± 5.1 kPa to 344.6 ± 42.6, 28.3 ± 4.6 kPa, and 78.3 ± 9.7 kPa, respectively. Cardiosphere derived cells were cultured on the scaffolds, and exhibited s.. Read More»
  DOI: 10.4172/2157-7552.S11-003

  Abstract PDF