Journal of Clinical Case Reports

Janis E Blair

Publications

• Case Report
  Fluconazole-Associated Hypercalcemia in Patients with Coccidioidomycosis
  Author(s): Nam H Chan, Janis E Blair, Sydney A Westphal, Leila K Tehrani and Maria Teresa A SevilleNam H Chan, Janis E Blair, Sydney A Westphal, Leila K Tehrani and Maria Teresa A Seville
  
  Fluconazole, voriconazole, and itraconazole may potentiate the hypercalcemic effect of other medications, although to date, triazoles alone have not been linked to hypercalcemia. We describe a case of new-onset hypercalcemia in the setting of high-dose fluconazole that resolved after changing the antifungal regimen. We reviewed our institutional database to assess the frequency of moderate or severe hypercalcemia (serum calcium ≥12 mg/dL) among patients with coccidioidomycosis treated with a triazole. We identified 2,133 patients, seen from January 1, 2005, through December 20, 2012, with a diagnosis of coccidioidomycosis. Twenty-three patients (1%) had subsequent hypercalcemia; of these, 20 patients (87%) had moderate or severe hypercalcemia. Nine of the 20 patients (45%) with moderate or severe hypercalcemia were taking triazoles, and most had comorbid conditions.. Read More»
  DOI: 10.4172/2165-7920.1000800

  Abstract PDF