Molecular Biomarkers & Diagnosis

Janusz Menkiszak

Publications

• Research Article
  Preoperative Diagnostic Performance of ROMA (Risk of Ovarian Malignancy Algorithm) in Relation to Etiopathogenesis of Epithelial Ovarian Tumors
  Author(s): Anita Chudecka-Glaz, Aneta Cymbaluk-Ploska, Janusz Menkiszak, Agnieszka Sompolska-Rzechula, Aleksandra Strojna, Elzbieta Byra, Aleksandra Toloczko-Grabarek and Izabella Rzepka-GórskaAnita Chudecka-Glaz, Aneta Cymbaluk-Ploska, Janusz Menkiszak, Agnieszka Sompolska-Rzechula, Aleksandra Strojna, Elzbieta Byra, Aleksandra Toloczko-Grabarek and Izabella Rzepka-Górska
  
  Background: We studied the usefulness of ROMA for preoperative stratification of patients in relation to the menopausal status, etiopathogenesis of epithelial ovarian tumors and FIGO stage. Material and methods: The study group (n=214) consisted of 116 premenopausal and 98 postmenopausal patients, including 83 with ovarian cancer and 131 with benign lesions. CA125 and HE4 were determined in each pre- and postmenopausal patient. ROC analysis was done to calculate the sensitivity, specificity, PPV, and NPV and a contingency table was applied to assess the usefulness of ROMA. Results: ROC analysis identified AUC (area under curve) as the most valuable component of ROMA (0.921) in the study group with respect to CA125 (0.919) and HE4 (0.855). Sensitivity was highest for CA125 (90.4% for the whole group, 85.7% for premenopausal and 91.7% fo.. Read More»
  DOI: 10.4172/2155-9929.S4-003

  Abstract PDF