Journal of Tissue Science and Engineering

Jaroslav Chlupac

Publications

• Research Article
  Endothelial Cell Lining of PET Vascular Prostheses: Modification with Degradable Polyester-based Copolymers and Adhesive Protein Multi-layers
  Author(s): Jaroslav Chlupac, Elena Filova, Tomas Riedel, Eduard Brynda, Elzbieta Pamula and Lucie BacakovaJaroslav Chlupac, Elena Filova, Tomas Riedel, Eduard Brynda, Elzbieta Pamula and Lucie Bacakova
  
  Background: Bypass surgery for atherosclerosis is confronted with the absence of endothelial cells in the lumen of vascular prosthesis in humans. This imposes a risk of thrombosis. New biomaterials try to minimize surface thrombogenicity. Methods: Knitted polyethylene terephthalate (PET) vascular graft patches were impregnated with degradable polyester polymers: poly (L-lactide-co-glycolide) (PLG) or poly (L-lactide-co-glycolide-co-ε-caprolactone) (PLGC). The luminal surface was coated with collagen type I (Co) to which extracellular matrix proteins laminin (LM), fibronectin (FN), or surface fibrin gel (Fb) were attached. Three types of prostheses (PET, PET–PLG and PET– PLGC) and 5 types of protein assemblies (+Co, +Co/LM, +Co/FN, +Co/Fb, +Co/Fb/FN) were fabricated. Scanning electron.. Read More»
  DOI: 10.4172/2157-7552.1000139

  Abstract PDF