Journal of Infectious Diseases and Medicine

Jay Vornhagen

Publications

• Short Communication
  Exploring the Pregnant Guinea Pig as a Model for Group B Streptococcus Intrauterine Infection
  Author(s): Maria I Harrell, Kellie Burnside, Christopher Whidbey, Jay Vornhagen, Kristina M Adams Waldorf and Lakshmi RajagopalMaria I Harrell, Kellie Burnside, Christopher Whidbey, Jay Vornhagen, Kristina M Adams Waldorf and Lakshmi Rajagopal
  
  Infection of the amniotic cavity remains a major cause of preterm birth, stillbirth, fetal injury and early onset, fulminant infections in newborns. Currently, there are no effective therapies to prevent in utero infection and consequent co-morbidities. This is in part due to the lack of feasible and appropriate animal models to understand mechanisms that lead to in utero infections. Use of mouse and rat models do not fully recapitulate human pregnancy, while pregnant nonhuman primate models are limited by ethical considerations, technical constraints, and cost. Given these limitations, the guinea pig is an attractive animal model for studying pregnancy infections, particularly as the placental structure is quite similar to the human placenta. Here, we describe our studies that explored the pregnant guinea pig as a model to study in utero Group B Streptococci (GBS) infections. We obse.. Read More»
  DOI: 10.4172/2576-1420.1000109

  Abstract PDF