Molecular Biomarkers & Diagnosis

Jayashree Bhattacharjee

Publications

• Review Article
  Study of TNF-α Polymorphism (308G/A) and the Role of NF-κB as an Novel Marker of Severity of Atherosclerosis: A Pilot Study in Indian Population
  Author(s): Arpita Suri, Ritu Singh, Sanjay Tyagi and Jayashree BhattacharjeeArpita Suri, Ritu Singh, Sanjay Tyagi and Jayashree Bhattacharjee
  
  Background: Biallelic polymorphism of A/G variation at position 308 in the promoter region of TNF-α gene is an important genetic factor causing high TNF-α transcription which could influence the clinical outcome of atherosclerosis. Studies have also implicated the role of NF-κB in atherogenesis by regulating genes involved in the inflammatory response and insulin sensitivity. Material and Method: 50 cases of angiographically significant atherosclerosis (>50% obstruction in coronary arteries) and 50 age, sex, BMI matched patients with insignificant atherosclerosis (>50% obstruction) on angiography were selected from GB Pant Hospital. Polymorphism was studied by amplifying DNA using PCR and amplified segments were digested by restriction enzyme Nco-I and followed by RFLP. Serum NF-κB, TNF-α levels were estimated by.. Read More»
  DOI: 10.4172/2155-9929.1000287

  Abstract PDF