General Biology Reproduction and Comparative Development,
UDL, Ecole Pratique des Hautes Etudes, PSL, 10, Place des Archives, F-69288 Lyon Cedex 02
France
Review Article
Amphibians as Models for the Study of Cell Proliferation, Differentiation and Apoptosis throughout Embryonic Development and Oviduct Cycles
Author(s): Jean-Marie Exbrayat, Claire Brun, Béatrice de Montera, Elara N Moudilou and Michel RaquetJean-Marie Exbrayat, Claire Brun, Béatrice de Montera, Elara N Moudilou and Michel Raquet
Amphibians are anamniotic vertebrates having conquered the terrestrial environment. Their reproduction and development occur in water. After metamorphosis, the animal leaves the water to live on the ground. Yet, some species remain in the water and certain of them are viviparous. Since a long time, amphibians are used such as animal models to understand physiological or developmental mechanisms. Today, amphibians can be used such as excellent models to understand the importance of cell proliferation, differentiation and death throughout embryonic development. A second way concerns the importance of these phenomena in the organs subjected to very sharp variations, alternation of differentiation/dedifferentiation throughout the sexual cycle, according to external or experimental conditions. The importance of apoptosis and of the presence of calpains has been noted throughout embryonic d.. Read More»
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