Medicinal Chemistry

Jean-Philippe Annereau

Publications

• Research Article
  Hemisynthesis of Anisomycin Derivatives as Antitumor Agents
  Author(s): Perrine Six, Jean-François Goossens, William Riquet, Viviane Brel, Emmanuel Fournier, Jean-Philippe Annereau, Anna Kruczynski, Omar Castillo-Aguilera, Patrick Depreux, Christian Bailly and Laurence GoossensPerrine Six, Jean-François Goossens, William Riquet, Viviane Brel, Emmanuel Fournier, Jean-Philippe Annereau, Anna Kruczynski, Omar Castillo-Aguilera, Patrick Depreux, Christian Bailly and Laurence Goossens
  
  The antibiotic anisomycin, secreted by Streptomyces griseolus, can induce tumor cell death and it displays antimetastatic activity coupled with induction of apoptosis. Herein we report the hemi-synthesis of 16 novel anisomycin derivatives and their biological activity. The protein synthesis inhibition and the effects on cancer cell proliferation and migration were assessed for two series of molecules to determine structure-activity relationships. The secondary amino group of anisomycin is essential to preserve the bioactivity. Although, the natural product is the most active component of the series but an active derivative has been identified .. Read More»
  DOI: 10.4172/2161-0444.1000262

  Abstract PDF