Service of Pathohistology, Clinical Center of Serbia,
Iran
Research Article
Immunohistochemical Approach to the Diagnosis of Adenocarcinoma of the Lung
Author(s): Jelena StojsicJelena Stojsic
Introduction: Differentiation between adenocarcinoma of the lung (LADC) from the other non-small cell lung carcinoma (NSCLC) is possible by immunohistochemistry. When diagnosis of LADC is established, the rest of lung cancer tissue could be used for molecular testings, particularly EGFR analysis
Aim: To evaluate 4 antibodies TTF-1, Napsin-A, Cytokeratin7 and Surfactant B in diagnosis of LADC.
Materialsand Methods: Fifty small-sized samples, obtained upon bronchoscopy or transthoracic fine-needle lung biopsy, were included in this study. Diagnosis of LADC was performed after routine hematoxylin-eosin examination and TTF-1, Napsin-A, Surfactant B and Cytokeratin7 immunohistochemistry. Descriptive statistical method (%) was used in the study.
Results: Cytokeratin7 was expressed in 90% (45/50), tha.. Read More»
DOI:
10.4172/2157-7099.1000229
Journal of Cytology & Histology received 2476 citations as per Google Scholar report