Molecular Biomarkers & Diagnosis

Jerzy Kozielski

Publications

• Research Article
  Increased Serum Hepatocyte Growth Factor (HGF) Levels in Patients with Idiopathic Pulmonary Fibrosis (IPF) or Progressive Sarcoidosis
  Author(s): Dariusz Ziora, Mariusz Adamek, Zenon Czuba, Dariusz Jastrzebski, Karolina Zeleznik, Slawomir Kasperczyk, Jerzy Kozielski and Wojciech KrolDariusz Ziora, Mariusz Adamek, Zenon Czuba, Dariusz Jastrzebski, Karolina Zeleznik, Slawomir Kasperczyk, Jerzy Kozielski and Wojciech Krol
  
  Background: Endogenous Hepatocyte Growth Factor (HGF) is required for self-repair of injured liver, kidneys and lungs. It also exerts a regenerative effect on epithelium. HGF can inhibit both the initiation and progression of lung fibrosis in Idiopathic Pulmonary Fibrosis (IPF). However available literature data on the role of HGF in sarcoidosis are scarce and conflicting. The aim of our study was to estimate and compare the serum concentrations of HGF both in patients with IPF and sarcoidosis and in healthy controls. Material and methods: In 43 patients with sarcoidosis, 17 patients with IPF and 20 healthy controls serum HGF concentrations were measured using multiplex bead based sandwich immunoassay. Results: In patients with IPF mean concentrations of HGF (1286.2 ± 238.3 pg/ml) were significantly higher t.. Read More»
  DOI: 10.4172/2155-9929.1000167

  Abstract PDF