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Research Article
Variations of the Tumor Position in Frameless Lung Sbrt: Assessment of Predictive Factors Including Tumor Volume Changes
Author(s): Jessica Schuster, Michael Myers, Mihaela Rosu, Nitai Mukhopadhyay and Elisabeth WeissJessica Schuster, Michael Myers, Mihaela Rosu, Nitai Mukhopadhyay and Elisabeth Weiss
Purpose: To quantify inter- and intrafractional variations of tumor position and analyze the relationship between these changes and respiratory motion amplitude, volume changes and tumor location, in frameless stereotactic body radiotherapy (SBRT) of lung tumors.
Materials and methods: Tumor volumes and bony landmarks were contoured manually by a single physician on 174 pre- and under treatment cone-beam computed tomographies (CBCTs) of 17 patients. The interfraction variation of the tumor position was measured by comparing the centroid position of the tumor relative to bony anatomy of each fraction to the pretreatment CBCT scans. The intrafraction variation was measured by comparing the pretreatment tumor location to under treatment CBCTs for every fraction. Respiratory motion was analyzed on planning 4D fan beam CTs for all p.. Read More»
DOI:
10.4172/2155-9619.1000147
Nuclear Medicine & Radiation Therapy received 706 citations as per Google Scholar report