Human Genetics & Embryology

Jian Zhang

Publications

• Review Article
  Induced Pluripotent Stem Cells: Origins and Directions
  Author(s): Wenjie Jiang, Jian Zhang, Xiaomei Yang and Jiangang GaoWenjie Jiang, Jian Zhang, Xiaomei Yang and Jiangang Gao
  
  Embryonic stem (ES) cells are used in various fields for diverse purposes, including gene targeting, cell therapy, tissue repair, organ regeneration, and so on. However, studies on and applications of ES cells are hindered by ethical disputes regarding cell source. To circumvent ethical issues, scientists have attempted to generate ES celllike cells, which are not derived from the inner cell mass of blastocyst-stage embryos. In 2006, Yamanaka first reprogrammed mouse embryonic fibroblasts into ES cell-like cells, which were called induced pluripotent stem (iPS) cells. Nearly a year later, the Yamanaka and Thomson laboratories independently reprogrammed human somatic cells into iPS cells. Since the establishment of the first iPS cell line, iPS cells have been derived from a number of different cell types and have been used for cell therapy, human disease modeling, and drug discovery. T.. Read More»
  DOI: 10.4172/2161-0436.S2-002

  Abstract PDF