Medicinal Chemistry

Jiao Yang

Publications

• Research Article
  Humulus Scandens Chemical Constituents Determination and Pharmacological Action Research
  Author(s): Zaixing Chen, Shu Meng, Jiao Yang, Hongguang Nie, Hong Jiang, Huiyuan Hu and Fanhao MengZaixing Chen, Shu Meng, Jiao Yang, Hongguang Nie, Hong Jiang, Huiyuan Hu and Fanhao Meng
  
  Humulus Scandens has been widely used for a long time in folk medicine, but it has not been systematically researched until now. The aims of this study were to isolate the components and simultaneously determine the contents of luteolin-7-O-β-D-glucoside (LGL) and apigenin-7-O-β-D-glucoside (AGL) in the different parts of H. Scandens. At the same time, our research team verified the anti-cancer activity and the alveolar fluid clearance (AFC) of H. Scandens total flavonoids (HSTF), LGL and AGL. The anti-cancer experiment showed that HSTH and LGL have a significant inhibition effect on the HepG2 cell. The cell viability decreased when drug concentration increased, but AGL has an indistinctive effect on HepG2 cell under the same concentration. The AFC experiment showed that AFCs of HSTF, LGL and AGL, compared to the blank control group, increased, which explained the H. Scanden.. Read More»
  DOI: 10.4172/2161-0444.1000109

  Abstract PDF