Jieyun Jiang
University Professor at Department of Microbiology
Biography
Jieyun Jiang is Professor in the Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Rose Street, Lexington, USA.His research interest was on Synthesis and Biological Evaluation of Novel Furozan-Based Nitric Oxide-Releasing Derivatives of 23-Hydroxy Betulinic Acid and 3-oxo-23- hydroxybetulinic acid as Potential Anti-Tumor Agents.
Research Interest
23-Hydroxy betulinic acid; NO-donor; Furozan; Antitumor activity, Lupane triterpenoids, Nitric oxide (NO), a free radical gas, is a key mediator involved in many physiological and pathological processes. High levels of NO and its metabolic derivatives, the reactive nitrogen species (RNS) and reactive oxygen species (ROS), can modify functional proteins by S-nitrosylation, nitration, and disulfide formation, leading to bio-regulation, inactivation, and cytotoxicity, particularly in tumor cells.
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