Cardiovascular Diseases & Diagnosis

Jillian Onufrak

Publications

• Research Article
  Neuregulin1 Improved Cardiac Function in Doxorubicin-Treated Mice with Cardiomyocyte-Specific over expression of a Dominant-Negative PI3Kp110α
  Author(s): Yun Bian, Marcy Silver, Jillian Onufrak, Kalon K.L. Ho, Mark A. Marchionni, Peter M Kang, David A Goukassian, Joseph Carrozza, James P Morgan and Xinhua YanYun Bian, Marcy Silver, Jillian Onufrak, Kalon K.L. Ho, Mark A. Marchionni, Peter M Kang, David A Goukassian, Joseph Carrozza, James P Morgan and Xinhua Yan
  
  Neuregulin1s (NRG1s) are effective for protecting the heart from various stresses. Our previous studies show that heterozygous knockout of the NRG1 gene worsens while injections of a recombinant NRG1 improve cardiac function in Chemotherapy Drug Doxorubicin (DOX) - treated mice. In cultured cardiomyocytes, studies show that the Phosphoinositide 3-Kinase (PI3K) pathway is necessary for NRG1 to reduce DOX-induced apoptosis and loss of cardiac troponins. Here, we test whether PI3Kp110α, a Class IA PI3K isoform, is necessary for NRG1’s cardioprotective effects in DOX-treated mice. DOX was administered to mice with cardiomyocyte-specific overexpression of a constitutively active PI3Kp110α (CaPI3K), or a dominant negative PI3Kp110α (dnPI3K). Solvent or NRG1 was administered concurrently with DOX to dnPI3K mice. Our results showed that survival and cardiac function we.. Read More»
  DOI: 10.4172/2329-9517.1000120

  Abstract PDF