Molecular Biomarkers & Diagnosis

Jing Zhang Wang

Publications

• Rapid Communication
  Clinical Benefits of the Classification of Cardiovascular Patients based on the Polymorphisms of Natriuretic Peptide Receptor Genes
  Author(s): Jing Zhang Wang, Xin-Hua Guo and Ting ZhangJing Zhang Wang, Xin-Hua Guo and Ting Zhang
  
  Natriuretic peptides (NPs NP) are supposed to be important biomarkers as well as therapeutic medicines for cardiovascular diseases, however, there are still some controversies blocking the clinical application of NPs. Especially, natriuretic peptide receptors (NPRs) greatly interfere with the indicative efficiency, therapeutic effectiveness, clinical dosage, and medication time of NPs. Herein, we propose that the classification of cardiovascular patients will effectively promote the clinical utilization of NPs as either biomarkers or medicines. Generally, NPs bind to natriuretic peptide receptor A and B (NPRA and NPRB) to activate cellular signalings, but natriuretic peptide receptor C (NPRC) is mainly responsible for the clearance of NPs. So, it is expected that high NPs-sensitivity group includes individuals carrying the alleles that result in higher activity of NPRA and NPRB and lo.. Read More»
  DOI: 10.4172/2155-9929.1000208

  Abstract PDF