Medicinal Chemistry

Jinghua Yu

Publications

• Research Article
  Use of a Quartz Crystal Microbalance for Studying the Effects of Propyl Gallate on the Interactions of Interleukin-6 and Its Soluble Receptor
  Author(s): Su Liu, Jiadong Huang, Qiang Chen and Jinghua YuSu Liu, Jiadong Huang, Qiang Chen and Jinghua Yu
  
  Quartz Crystal Microbalance (QCM) is known as a surface sensitive analytical device capable of on-line monitoring of interfacial reactions. To study the interaction between interleukin-6 (IL-6) and its soluble receptor (sIL-6R), as well as the effects of propyl gallate on IL-6/sIL-6R binding based on it, a QCM was employed to monitor the binding responses. In the experiments, sIL-6R was immobilized on the surface of QCM substrate, then different concentrations of IL-6 were added onto the substrate, respectively. The response frequency shift caused by the binding between IL-6 and sIL-6R was recorded. The results showed that sIL-6R was immobilized on the substrate surface with the density of 3.43 ng/mm2, IL-6 then bound to the immobilized sIL-6R specifically. FAST fit program was used to analyse the data obtained of the association of IL-6 and immobiliz.. Read More»
  DOI: 10.4172/2161-0444.1000263

  Abstract PDF