Neurological Disorders

João Paulo Farias

Publications

• Case Report
  Seronegative Wegener’s Granulomatosis Presenting as a Multiple Cranial Neuropathy
  Author(s): Sara Machado, Amélia Nogueira Pinto, Nuno Inácio, Filipe Paulas, Luísa Biscoito, João Paulo Farias, Marta Amaral and José AlvesSara Machado, Amélia Nogueira Pinto, Nuno Inácio, Filipe Paulas, Luísa Biscoito, João Paulo Farias, Marta Amaral and José Alves
  
  Wegener’s granulomatosis (WG) is an immune-mediated systemic vasculitis of unknown etiology that can be seen in almost any system. It classically affects the upper and lower airways, lungs and kidneys. Despite its possibility of generalization, neurological involvement is hardly seen. When it occurs, WG tends to affect the peripheral nervous system, often as sensory-motor polyneuropathy or mononeuritis multiplex. Involvement of cranial nerves is much less frequent, and the most affected is the optic nerve. Involvement of the central nervous system is even rarer but there are reports including cerebrovascular events, seizures, cerebritis, diabetes insipidus and pachymeningitis. In 1990, four criteria have been identified for the clinical diagnosis of WG by the American College of Rheumatology, which are still in effect and include upper airways inflammation, pulmonary nodules and.. Read More»
  DOI: 10.4172/2329-6895.1000149

  Abstract PDF