Journal of AIDS & Clinical Research

Johanna Ledwaba

Publications

• Research Article
  Drug Resistance Patterns and Virus Re-Suppression among HIV-1 Subtype C Infected Patients Receiving Non-Nucleoside Reverse Transcriptase Inhibitors in South Africa
  Author(s): Ziad El-Khatib, Allison K. DeLong, David Katzenstein, Anna Mia Ekstrom, Johanna Ledwaba, Lerato Mohapi, Fatima Laher, Max Petzold, Lynn Morris and Rami KantorZiad El-Khatib, Allison K. DeLong, David Katzenstein, Anna Mia Ekstrom, Johanna Ledwaba, Lerato Mohapi, Fatima Laher, Max Petzold, Lynn Morris and Rami Kantor
  
  Background: Emergence of HIV-1 drug resistance is at times an inevitable and anticipated consequence of antiretroviral therapy (ART) failure. We examined drug resistance patterns and virus re-suppression among subtype C-infected South African patients receiving first-line ART. Methods: Treatment records of 431 patients on NNRTI-containing regimens for a median of 45 months were analyzed. Patients with viral load (VL) >400 copies/mL were followed and drug resistance mutations (DRM) were re-assessed. Associations between clinical/demographic measures and drug resistance/virologic outcomes were examined using Fisher exact and ordinal and logistic regression. Results: Ten percent of patients (43/431) were viremic at enrollment (98%) sequences were obtained from 38/43. Of those, 82% had 1-7 DRM. In bivariate analysis remote exposure to single-dose nevirapine or prior AR.. Read More»
  DOI: 10.4172/2155-6113.1000117

  Abstract PDF