Pulmonary & Respiratory Medicine

Johnson Jean

Publications

• Case Report
  Airway-Centered Granulomatous Fibrinous and Organizing Pneumonia as a Manifestation of Sirolimus-A Reversible Pulmonary Toxicity
  Author(s): Andrews Arthur, Sriaroon Chakrapol, Rumbak Mark, Prendes Barbara, Johnson Jean, Leslie Kevin, Matta Amir and Solomon DavidAndrews Arthur, Sriaroon Chakrapol, Rumbak Mark, Prendes Barbara, Johnson Jean, Leslie Kevin, Matta Amir and Solomon David
  
  Sirolimus is a potent immunosuppressant medication and is used in renal transplant patients to prevent acute graft rejection. Various pulmonary toxicities in patients treated with sirolimus include cough, desquamative interstitial pneumonia (DIP), diffuse interstitial pneumonia, diffuse alveolar damage (DAD), diffuse alveolar hemorrhage (DAH), alveolar phospholipoproteinosis and pulmonary hypertension with features of hemolytic uremic syndrome (HUS). We describe a case of a patient with an insidious development of chest X-ray (CXR), computed tomography of the chest (CT chest) and pulmonary function (PFT) (mainly the DLCO) abnormalities. When this progressed, an open lung biopsy was performed revealing granulomatous inflammation consistent with a hypersensitivity reaction. The abnormalities on imaging and pulmonary function testing imp.. Read More»
  DOI: 10.4172/2161-105X.1000362

  Abstract PDF