Molecular and Genetic Medicine

Jonckx Bart

Publications

• Review Article
  Selection Strategy of In Vivo Models for Ophthalmic Drug Development in Diabetic Retinopathy
  Author(s): Reyns Geert E, Hu Tjing-Tjing, Van Bergen Tine, Etienne Isabelle, Willekens Koen, Jonckx Bart and Feyen Jean HMReyns Geert E, Hu Tjing-Tjing, Van Bergen Tine, Etienne Isabelle, Willekens Koen, Jonckx Bart and Feyen Jean HM
  
  Diabetic Retinopathy (DR) is the most common microvascular complication of diabetes and is one of the leading causes of visual impairment worldwide. DR is a chronic eye disease that eventually can result in legal blindness due to the evolution towards the major vision-threatening disorders diabetic macular edema (DME) and/or proliferative diabetic retinopathy (PDR). Current treatments with steroids, anti-VEGF compounds or retinal laser photocoagulation have shown a significant improvement in visual acuity in the advanced stage of the disease. However, main concerns are possible side effects and/or the relatively large number of clinical non-responders. A better understanding of the biological and molecular pathways not only in DR patients but also in the preclinical in vivo models would aid the development of novel and more efficient (personalized) therapeutic approaches for DR. This .. Read More»
  

  Abstract PDF