Journal of Clinical Case Reports

Jorge Aponte

Publications

• Case Report
  POEMS Syndrome: A Multidisciplinary Diagnostic Challenge
  Author(s): Leonardo Enciso, Jorge Aponte, Daniel Rodriguez, Carmenza Sandoval and Hernán GomezLeonardo Enciso, Jorge Aponte, Daniel Rodriguez, Carmenza Sandoval and Hernán Gomez
  
  POEMS syndrome is a paraneoplastic phenomenon associated with polyneuropathy and paraproteinemia that arises out of the clonal expansion of plasma tumor cells. Its other distinguishing features include sclerotic bone lesions, increased vascular endothelial growth factor levels, Castleman disease alterations in lymph node biopsy and association with organomegaly, endocrinopathy, cutaneous lesions, papilledema, extravascular volume overload and thrombocytosis. Although established diagnostic criteria exist, the fact that the disease is rare and shares similar clinical manifestations with non-neoplastic conditions means that in most cases patients are diagnosed at latestage, when multiple complications have appeared and treatments for other conditions have already been given. Therefore, a high degree of suspicion combined with a multidisciplinary approach are requisites for attaining pre.. Read More»
  DOI: 10.4172/2165-7920.1000979

  Abstract PDF