Journal of Metabolic Syndrome

Jorge Luis Rosado

Publications

• Research Article
  Effects of Combined Resveratrol Plus Metformin Therapy in db/db Diabetic Mice
  Author(s): Duarte-Vázquez Miguel Ángel, Gómez-Solís María Antonieta, Gómez-Cansino Rocio, Reyes-Esparza Jorge, Jorge Luis Rosado and Rodríguez-Fragoso LourdesDuarte-Vázquez Miguel Ángel, Gómez-Solís María Antonieta, Gómez-Cansino Rocio, Reyes-Esparza Jorge, Jorge Luis Rosado and Rodríguez-Fragoso Lourdes
  
  Background: The worldwide prevalence of Type 2 diabetes mellitus is associated with other conditions that trigger metabolic syndrome. Although several studies on the benefits of resveratrol have been carried out, few have assessed this drug in combination with metformin. Objectives: This study looks at the effects that combined metformin/resveratrol therapy has on body weight gain and liver and renal damage of db/db diabetic mice. It also addresses biochemical findings. Method: Diabetic mice were treated with resveratrol (20 mg/kg/day), metformin (150 mg/kg/day) and combined metformin/resveratrol therapy for 5 weeks. Histopathological tissue analyses and biochemical parameters (glucose, insulin, triglycerides and cholesterol), functional liver enzymes (AP, AST and GGT) and renal parameters (urea and uric acid) were examined. Results: Our data clearly showed that combined metformin/r.. Read More»
  DOI: 10.4172/2167-0943.1000217

  Abstract PDF