Journal of Metabolic Syndrome

Jorge Reyes Esparza

Publications

• Research Article
  Resveratrol Combined with Pioglitazone Ameliorates Cardiovascular Complications in db/db Diabetic Mice
  Author(s): Miguel Ángel Duarte-Vázquez, Antonieta Gomez Solis, Jorge Reyes Esparza, Jorge Luis Rosad and Lourdes Rodríguez FragosoMiguel Ángel Duarte-Vázquez, Antonieta Gomez Solis, Jorge Reyes Esparza, Jorge Luis Rosad and Lourdes Rodríguez Fragoso
  
  Type 2 Diabetes Mellitus patients are predisposed to serious cardiovascular morbidity and mortality. Diabetes causes different structural and functional alterations in the myocardial tissue, which are induced by hyperglycemia, insulin resistance, and hyperlipidemia. The resulting cardiomyopathy is characterized by myocardial fibrosis, dysfunctional remodeling and eventually, clinical heart failure. This study addressed the effects of resveratrol and pioglitazone to ameliorate diabetic cardiovascular complications using a db/db diabetic mice model. Male db/db diabetic mice were randomly assigned to orally receive resveratrol (50 mg/kg, n=5), resveratrol/pioglitazone (50 mg/kg and 20 mg/day, respectively, n=5) for the space of 6 weeks. Non-diabetic lean mice (n=5) were included as a control group. Histopathological analyses were performed in heart and aortic vessel tissue samples using .. Read More»
  DOI: 10.4172/2167-0943.1000243

  Abstract PDF