Molecular Biomarkers & Diagnosis

José Manuel Martínez-Martos

Publications

• Research Article
  Effects of Dietary Fat on Mammary Gland Pyroglutamyl Aminopeptidase on Experimental Breast Cancer
  Author(s): María Jesús Ramírez-Expósito, María Dolores Ruíz-Sanjuan and José Manuel Martínez-MartosMaría Jesús Ramírez-Expósito, María Dolores Ruíz-Sanjuan and José Manuel Martínez-Martos
  
  Aim: To analyze the relationship between dietary fat and breast cancer mediated by the local functions of gonadotropin-releasing hormone (GnRH), analyzed by its regulating peptidase. The presence of GnRH and its receptors has been demonstrated in tumor tissue of the breast, although the functions of this peptide remain unclear. Pyroglutamyl aminopeptidase (PAP) is the enzyme involved in the local regulation of GnRH, and changes in its soluble and membrane-bound activities have been described in both women with breast cancer and animals with mammary tumors induced by N-methyl nitrosourea (NMU). Methods: We analyze here the effects of different normolipidic (4%) dietary fats (soybean oil (commercial), extra virgin olive oil (EVOO), refined sunflower oil (SO) and refined sunflower oil enriched with 50% oleic acid (OAESO)) on soluble and membrane-bound PAP specific activities in breast tissu.. Read More»
  DOI: 10.4172/2155-9929.1000392

  Abstract PDF