Journal of Clinical & Medical Genomics

Jose C Casali-da-Rocha

Publications

• Research Article
  ONCOTARGET (ONCOALVO), a Custom NGS Panel for Therapeutic Decision in Solid Tumors Refractory to Conventional Therapy
  Author(s): Andre M Murad, Jose C Casali-da-Rocha, Juliana G Carneiro and Ana LB GodardAndre M Murad, Jose C Casali-da-Rocha, Juliana G Carneiro and Ana LB Godard
  
  Next-generation Sequencing (NGS) of tumor biopsies of both solid tumors, as well as hematological malignancies, using commercially available platforms has broadly entered routine clinical practice in medical oncology. This molecular diagnostic approach is now used mainly to test for predictive biomarkers for patients with no available further standard therapies, as diagnostics rely on genomic testing of molecular alterations to enable effective cancer treatment. However, the high cost of large multigenic panels and especially the sequencing of the entire tumor exome is a concern, especially in a developing country such as Brazil. Here we report the clinical application of a panel of 57 genes that we call ONCOTARGET (ONCOALVO) which is based on the Thermo Fisher Oncomine Focus Assay, an integrated, commercially available NGS assay for the rapid and simultan.. Read More»
  DOI: 10.4172/2472-128X.1000151

  Abstract PDF