Molecular Biomarkers & Diagnosis

Joseph C Maroon

Publications

• Review Article
  Gradual Return to Play: Potential Role of Neurotoxicity Biomarkers in Assessment of Concussions Severity
  Author(s): Svetlana A Dambinova, Richard L Sowell and Joseph C MaroonSvetlana A Dambinova, Richard L Sowell and Joseph C Maroon
  
  This mini-review analyzes advantages and limitations of current methods of assessment of cerebral concussions considering functional, structural and metabolic factors in decision making for return to play. Novel neurotoxicity biomarkers, AMPA and NMDA receptor peptide/antibodies are proposed for evaluation of subtle brain injury following concussions. Neurotoxicity biomarkers can now be detected in the blood and are associated with severity of concussion and transient or persistent changes in the brain including diffuse axonal injury and microvascular dysfunction (edema formation). We surveyed 84 students (20.5 ± 2.5 years) participating in contact-sports and enrolled at Kennesaw State University. Based on neurotoxicity biomarkers values and diminished ImPACT scores, 18 athletes with concussions were selected for longitudi.. Read More»
  DOI: 10.4172/2155-9929.S3-003

  Abstract PDF