Molecular Biology: Open Access

Joseph Molnár

Publications

• Research Article
  Synergism between Antiplasmid Promethazine and Antibiotics In Vitro and In Vivo
  Author(s): Joseph Molnár, Yvette Mándi, Gabriella Spengler, Leonard Amaral, Ibolya Haszon, Sándor Turi and Miklós KáslerJoseph Molnár, Yvette Mándi, Gabriella Spengler, Leonard Amaral, Ibolya Haszon, Sándor Turi and Miklós Kásler
  
  Four large groups of antibiotics were developed for different targets of bacterial cells which differ from those of human cells. Uncontrolled use of antibiotics, resistance soon followed. Today, the majorities of bacterial infections are caused by multidrug resistant bacterial isolates and result in serious treatment difficulties. The main cause for antibiotic resistance is the acquisition of plasmids which carry antibiotic resistant genes. These extra-chromosomal genetic elements can be eliminated by phenothiazines from antibiotic resistant bacteria by the selective inhibition of plasmid replication over that of the plasmid carrying bacterium at three different levels or steps as follows: 1. replication of plasmid DNA is destabilized due to the drug induced relaxation of super-helical structure of replicative form of plasmid DNA; 2. inhibition of partition of plasmid DNA during the c.. Read More»
  DOI: 10.4172/2168-9547.1000119

  Abstract PDF