Journal of Tissue Science and Engineering

Joseph Temple

Publications

• Research Article
  Multiphase Biodegradable Scaffolds for Tissue Engineering a Tendon-Bone Junction
  Author(s): Harshini Ramakrishna, Tieshi Li, Ting He, Joseph Temple, Martin W King and Anna SpagnoliHarshini Ramakrishna, Tieshi Li, Ting He, Joseph Temple, Martin W King and Anna Spagnoli
  
  Tendons play an important role in transferring stress between muscles and bones and in maintaining joint stability. Tendon tears are difficult to heal, and are associated with high recurrence rates. So the objective of this study was to develop a biodegradable scaffold for tendon-bone junction regeneration. Two types of polylactic acid (PLA) yarns, having fibers with round and four deep grooved cross-sections, were braided into tubular scaffolds and cultured with murine TGF-β Type II receptor (TGFBR2)-expressing joint progenitor cells. The scaffolds were designed to mimic the mechanical, immuno-chemical and biological properties of natural mouse tendon-bone junctions. Three different tubular scaffolds measuring 2 mm in diameter were braided on a Steeger 16-spindle braiding machine using these PLA yarns. The three different scaffold structures were: 1) PLA hollow tube using round .. Read More»
  DOI: 10.4172/2157-7552.1000211

  Abstract PDF