Medicinal Chemistry

Juan Diego Maya

Publications

• Research Article
  Synthesis and Trypanocidal Properties of New Coumarin-Chalcone Derivatives
  Author(s): Saleta Vazquez-Rodriguez, Roberto Figueroa Guíñez, Maria João Matos, Claudio Olea-Azar, Juan Diego Maya, Eugenio Uriarte, Lourdes Santana and Fernanda BorgesSaleta Vazquez-Rodriguez, Roberto Figueroa Guíñez, Maria João Matos, Claudio Olea-Azar, Juan Diego Maya, Eugenio Uriarte, Lourdes Santana and Fernanda Borges
  
  With the aim of finding new chemical entities based on coumarin and chalcone scaffolds, new hybrid compounds 2-5 were designed and synthesized. The trypanocidal activity of these compounds was tested against the epimastigote, trypomastigote and amastigote stages of the Trypanosoma cruzi parasite. Cytotoxicityassays were also performed in RAW 264.7 and VERO cells. Compound 5 presented the highest trypanocidal activity of the series, with trypanocidal values higher than Nifurtimox for the trypomastigote and epimastigote stages., but presenting cytotoxic effects in the mammalian cells. A SAR study suggested that methoxy substitution at positions 2’ and 5’ in the designed scaffold seemed to be a key feature for the trypanocidal activity. Therefore, the coumarin-chalcone scaffold can be taken into account for f.. Read More»
  DOI: 10.4172/2161-0444.1000260

  Abstract PDF