Journal of Sports Medicine & Doping Studies

Julien S Baker

Publications

• Review Article
  Genetic Predictors of Adenosine Monophosphate Deaminase Deficiency
  Author(s): Lawrence D Hayes, Fraser E Houston and Julien S BakerLawrence D Hayes, Fraser E Houston and Julien S Baker
  
  In the majority of the population, during high intensity exercise, Adenosine Monohosphate Deaminase (AMPD) Converts Adenosine Monophosphate (AMP) to Inosine Monophosphate (IMP), with the liberation of ammonia in the process. The AMPD reaction displaces the adenylate kinase equilibrium in the direction of ATP formation during exercise, providing additional energy and preventing a large increase in ADP. AMPD deficiency has been proposed to result in faster fatigue development and earlier inhibition of muscle contractions. This review considers a number of genetic mutations that lead to skeletal muscle AMPD deficiency, their pathology and likely symptoms of the disorder... Read More»
  DOI: 10.4172/2161-0673.1000124

  Abstract PDF