Journal of Clinical Case Reports

Julio Sergio Marchini

Publications

• Case Report
  Oxidative Stress after Iron Supplementation in Crohn's Disease
  Author(s): Marcia Morandi Varela Junqueira-Franco, Carolina Ferreira Nicoletti, Carla Barbosa Nonino, Hélio Vannucchi and Julio Sergio MarchiniMarcia Morandi Varela Junqueira-Franco, Carolina Ferreira Nicoletti, Carla Barbosa Nonino, Hélio Vannucchi and Julio Sergio Marchini
  
  Crohn’s disease is a chronic inflammatory intestinal disease associated with increased of pro-inflammatory cytokines, iron deficiency and anaemia. This case report demonstrates a strategy for intravenous iron supplementation in a patient with Crohn´s disease and severe anaemia. This study found an increased in iron and haemoglobin concentrations, malondialdehyde and superoxide dismutase levels and a reduction in glutathione peroxidase (GPx), vitamin A and E. In conclusion the use of intravenous iron probably leads to increase ROS production; this effect may be reduced by using polivitaminics, and enhanced the free radical scavenger. .. Read More»
  DOI: 10.4172/2165-7920.1000858

  Abstract PDF