Pt. B D Sharma PGIMS Rohtak,
Haryana
India
Case Report
Valproate Induced Hyperammonemic Encephalopathy in a Patient with Phenytoin Toxicity: A Case Report
Author(s): Juneja H, Dabla S and Pahuja IJuneja H, Dabla S and Pahuja I
Valproate is an antiepileptic drug which is commonly used for the treatment of focal and/or generalized epilepsy and mood disorders. Valproate is one of the safest first line antiepileptic drug, but like any other drug, it has adverse effects such as nausea, vomiting, drowsiness, tremors, alopecia, menstrual irregularities, polycystic ovarian disease, hepatotoxicity, pancreatitis, thrombocytopenia and rarely hyperammonemia etc. We have reported a case of 22-years-old female of idiopathic generalized epilepsy admitted with eptoin toxicity and subsequently she developed valproate induced non-hepatic hyperammonemia encephalopathy during her hospital stay. Valproate was withheld immediately, and her symptoms resolved after 48 hours... Read More»
DOI:
10.4172/2165-7920.10001128
Journal of Clinical Case Reports received 1295 citations as per Google Scholar report