Journal of Tissue Science and Engineering

Junichiro Yokawa

Publications

• Research Article
  Enhanced Device for Cell Delivery to the Myocardium: Validation in Swine Hearts
  Author(s): Junichiro Yokawa, Chiaki Nakanishi, Masayuki Mori, Kenji Sakata, Hirofumi Okada, Masaya Shimojima, Shohei Yoshida, Kenshi Hayashi, Masakazu Yamagishi and Masa-aki KawashiriJunichiro Yokawa, Chiaki Nakanishi, Masayuki Mori, Kenji Sakata, Hirofumi Okada, Masaya Shimojima, Shohei Yoshida, Kenshi Hayashi, Masakazu Yamagishi and Masa-aki Kawashiri
  
  Background: Endocardial infusion is a minimally invasive procedure for cell delivery with good selectivity to the target region. However, certain limitations to current devices could affect the precision of the procedure and the therapeutic outcome. Therefore, we developed an enhanced device for transendocardial cell infusion. Methods and Results: Our device is based on an electrode-guided transendocardial bidirectional 75 cm long catheter and 0.5 mm diameter inner needle. The key advantages of our device are the slender catheter diameter (7 Fr), consistent needle tip length, regulation of the catheter angle and independence between the needle and catheter. Mesenchymal stem cells (MSCs) were obtained from the inguinal adipose tissue of six healthy swine and propagated through 2-3 passages. Using the catheter, pre-labeled MSCs were infused autogenously into the swine hearts. The MSCs-i.. Read More»
  DOI: 10.4172/2157-7552.1000204

  Abstract PDF