Molecular Biomarkers & Diagnosis

Jun-ya Harada

Publications

• Research Article
  Identification of Cerebral Infarction-Specific Antibody Markers from Autoantibodies Detected in Patients with Systemic Lupus Erythematosus
  Author(s): Ken-ichiro Goto, Takao Sugiyama, Ryutaro Matsumura, Xiao-Meng Zhang, Risa Kimura, Akiko Taira, Emiko Arita, Katsuro Iwase, Eiichi Kobayashi, Yasuo Iwadate, Naokatsu Saeki, Masahiro Mori, Akiyuki Uzawa, Mayumi Muto, Satoshi Kuwabara, Minoru Takemoto, Kazuki Kobayashi, Harukiyo Kawamura, Ryoichi Ishibashi, Ken-ichi Sakurai, Masaki Fujimoto, Koutaro Yokote, Takashi Nakayama, Jun-ya Harada, Yoshio Kobayashi, Mikiko Ohno, Hirotoshi Chin, Eiichiro Nishi, Toshio Machida, Yo Iwata, Seiichiro Mine, Ikuo Kamitsukasa, Takeshi Wada, Akiyo Aotsuka, Kaoru Katayama, Yuriko Kikkawa, Kenro sunami, Hirotaka Takizawa, Rika Nakamura, Go Tomiyoshi, Natsuko Shinmen, Hideyuki Kuroda and Takaki HiwasaKen-ichiro Goto, Takao Sugiyama, Ryutaro Matsumura, Xiao-Meng Zhang, Risa Kimura, Akiko Taira, Emiko Arita, Katsuro Iwase, Eiichi Kobayashi, Yasuo Iwadate, Naokatsu Saeki, Masahiro Mori, Akiyuki Uzawa, Mayumi Muto, Satoshi Kuwabara, Minoru Takemoto, Kazuki Kobayashi, Harukiyo Kawamura, Ryoichi Ishibashi, Ken-ichi Sakurai, Masaki Fujimoto, Koutaro Yokote, Takashi Nakayama, Jun-ya Harada, Yoshio Kobayashi, Mikiko Ohno, Hirotoshi Chin, Eiichiro Nishi, Toshio Machida, Yo Iwata, Seiichiro Mine, Ikuo Kamitsukasa, Takeshi Wada, Akiyo Aotsuka, Kaoru Katayama, Yuriko Kikkawa, Kenro sunami, Hirotaka Takizawa, Rika Nakamura, Go Tomiyoshi, Natsuko Shinmen, Hideyuki Kuroda and Takaki Hiwasa
  
  Background: Systemic lupus erythematosus (SLE) is an autoimmune disease which may be caused by development of the autoantibodies. On the other hand, SLE is a high-risk group of atherosclerosis, so it is possible that some of autoantibodies in SLE are the result of atherosclerosis-related diseases such as cerebral infarction (CI), cardiovascular disease (CVD) and diabetes mellitus (DM). Methods: The initial screening of autoantibodies was performed using the protein array method. AlphaLISA was used to analyze the serum antibody levels using synthetic polypeptides as antigens. Results: After the initial screening using protein array, we identified 67 antigens that were recognized by IgG antibodies in sera of patients with SLE. In the second screening, 170 peptides derived from amino acid sequences of 67 antigens were.. Read More»
  DOI: 10.4172/2155-9929.1000219

  Abstract PDF