Journal of AIDS & Clinical Research

Justen Manasa

Publications

• Review Article
  HIV Drug Resistance Patterns at the Epicentre of the HIV-1 Epidemic in Kwazulu-Natal, South Africa 2003-2013
  Author(s): Photini Kiepiela, Justen Manasa, Mahomed-Yunus Moosa, Pravi Moodley, Michelle Gordon, Urvi M Parikh, Henry Sunpath, Tulio de Oliveira and Gita RamjeePhotini Kiepiela, Justen Manasa, Mahomed-Yunus Moosa, Pravi Moodley, Michelle Gordon, Urvi M Parikh, Henry Sunpath, Tulio de Oliveira and Gita Ramjee
  
  South Africa has the highest number of individuals with HIV-1 infection worldwide with the epicentre of the epidemic in the province of KwaZulu-Natal (KZN). Currently South Africa has the largest antiretroviral treatment (ART) programme with KZN and Gauteng provinces accounting for 56% of all patients on ART. In order to understand transmission dynamics and temporal trends in drug resistance, we performed a comprehensive literature review of primary and acquired drug resistance in adults and children in KZN over a ten year period, 2003-2013. Transmitted drug resistance (TDR) to non-nucleoside reverse transcriptase inhibitors (NNRTIs) in adults is increasing to moderate levels (5-15%). Acquired drug resistance to first line drug regimens in adults was associated with at least one mutation to nucleoside reverse transcriptase inhibitors (NRTI) or NNRTIs or both, with M184V and K103N the .. Read More»
  DOI: 10.4172/2155-6113.1000299

  Abstract PDF