Iraq
Research Article
Cholinesterase Effects of Pesticides in Rabbit Embryos and their Potential for Use in Hazard Assessment
Author(s): Kasim Sakran Abass and Kamal Ali SalihKasim Sakran Abass and Kamal Ali Salih
Cholinesterase are often taken as biomarkers of exposure and effect. Then acetylhydrolase isozymes and acylcholine acylhydrolase were examined for their suitability as biomarkers of pesticide exposure. The study of effects of embryos of the rabbit is already an accepted tool in monitor food waste levels, but effects of various groups of substances to the rabbit embryo remain to be studied. A 43% inhibition of acetylhydrolase enzyme activities was reached by 250 mg/kg malathion, while 35% inhibition of acylcholine acylhydrolase enzyme activities was reached by 500 mg/kg malathion indicating the possible use of these enzymes as biomarkers of exposure. There are found some significant specific activities of the acetylhydrolase ranged from 1.5-7.1 U mg−1 protein. The specific activity of acylcholine acylhydrolase in the range of 0.9-4.5 U mg−1 protein in the respective develop.. Read More»
DOI:
10.4172/2157-7579.1000401
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