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Journal of Clinical Case Reports

ISSN: 2165-7920

Open Access

Kanae Saga


Japan

Publications
  • Case Report
    Report of Two Dental Patients Diagnosed with Hypophosphatasia
    Author(s): Rena Okawa, Taichi Kitaoka, Kanae Saga, Keiich Ozono and Kazuhiko NakanoRena Okawa, Taichi Kitaoka, Kanae Saga, Keiich Ozono and Kazuhiko Nakano

    Hypophosphatasia is a rare inherited skeletal disorder characterized by defective bone mineralization and tissue non-specific alkaline phosphatase (TNSALP) deficiency, with mutations in the gene encoding the TNSALP isozyme the cause. As for dental manifestations, premature loss of primary teeth due to disturbed cementum formation is well known and tooth roots in affected patients are not able to adequately attach to absorbed alveolar bone due to malformed cementum. We report spontaneous early exfoliation along with mild to severe mobility of primary anterior teeth in 2 child patients referred to pediatric dentists from a general dental practitioner. Case 1 was a 1-year-7- month-old boy with 3 mandibular incisors exfoliated, while Case 2 was a 3-year-3-month-old girl with 1 mandibular central incisor exfoliated. The possibility of hypophosphatasia was considered and the patients were r.. Read More»
    DOI: 10.4172/2165-7920.1000704

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