Journal of Blood & Lymph

Kanesbi MM

Publications

• Research Article
  Laboratory Assays in Patients with Acute Promyelocytic Leukemia and FLT3-TKD Mutations
  Author(s): Kanesbi MM, Jarahi L, Ayatollahi H, Sheikhi M and Siyadat PKanesbi MM, Jarahi L, Ayatollahi H, Sheikhi M and Siyadat P
  
  Acute Promyelocytic Leukemia (APL) is a well-characterized subtype of Acute Myeloid Leukemia (AML). The majority of patients with acute promyelocytic leukemia harbor the reciprocal translocation of t(15;17)(PML-RARα). Recent studies have shown that FMS-Like tyrosine kinase receptor-3 (FLT-3) mutations occur in approximately onethird of AML patients. Two major categories of clinically significant FLT3 activating mutations have been identified: Internal tandem duplication (ITD) mutations within the juxtamembrane domain of FLT-3 gene and missense point mutations in the tyrosine kinase domai. Several studies have demonstrated a poor overall survival with FLT-3 ITD mutation which is found in approximately 20-40% of AML patients. In contrast, the prognostic significance of FLT-3 TKD alone is still unclear, but some studies indicate that it also confers a poor prognosis in AML patients.. Read More»
  DOI: 10.37421/jbl.2019.9.256

  Abstract PDF