Cancer Science & Therapy

Kang Mei Chen

Publications

• Commentary
  Distinct Gene Profiles for Tumor and Non-Tumor Tissue in the Head and Neck: An Analytical Approach
  Author(s): Mei Lu, Josena K Stephen, Kang Mei Chen, Shaleta Havard and Maria J. WorshamMei Lu, Josena K Stephen, Kang Mei Chen, Shaleta Havard and Maria J. Worsham
  
  In a study of genetic alterations, the Multiplex Ligation-dependent Probe Amplification (MLPA) assay was used to measure gain or loss of 113 gene-probes in tumor and non-tumor tissue samples collected from each of the 220 patients with squamous head and neck cancer (HNSCC). Conditional and marginal models were available; both models account for correlated data but have different aspects. The conditional logistic regression model was proposed to estimate the subject-specific risk of tumor based on the paired tumor and non-tumor data collection, which was in contrast with the marginal model to estimate population-average risk. The modeling process included rigorous variable selection, an initial multivariable model, a final model selection, and model validation. Genes with individual effect (p<0.01) were considered as candidates for the initial multivariable model for tumor. .. Read More»
  DOI: 10.4172/1948-5956.S5-001

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